Ontology highlight
ABSTRACT:
SUBMITTER: Ovchinnikova E
PROVIDER: S-EPMC5918264 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Ovchinnikova Ekaterina E Hoes Martijn M Ustyantsev Kirill K Bomer Nils N de Jong Tristan V TV van der Mei Henny H Berezikov Eugene E van der Meer Peter P
Stem cell reports 20180215 3
Cardiac hypertrophy accompanies many forms of cardiovascular diseases. The mechanisms behind the development and regulation of cardiac hypertrophy in the human setting are poorly understood, which can be partially attributed to the lack of a human cardiomyocyte-based preclinical test system recapitulating features of diseased myocardium. The objective of our study is to determine whether human embryonic stem cell-derived cardiomyocytes (hESC-CMs) subjected to mechanical stretch can be used as an ...[more]