Ontology highlight
ABSTRACT:
SUBMITTER: Zhang RR
PROVIDER: S-EPMC5919071 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Zhang Ran-Ran RR Koido Masaru M Tadokoro Tomomi T Ouchi Rie R Matsuno Tatsuya T Ueno Yasuharu Y Sekine Keisuke K Takebe Takanori T Taniguchi Hideki H
Stem cell reports 20180208 3
Early endoderm progenitors naturally possess robust propagating potential to develop a majority of meter-long gastrointestinal tracts and are therefore considered as a promising source for therapy. Here, we demonstrated the reproducible generation of human CDX2<sup>+</sup> posterior gut endoderm cells (PGECs) from five induced pluripotent stem cell clones by manipulating FGF, TGF, and WNT signaling. Transcriptome analysis suggested that putative PGECs harbored an intermediate signature profile b ...[more]