Ontology highlight
ABSTRACT:
SUBMITTER: Jeong J
PROVIDER: S-EPMC5919404 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Jeong Jinsun J Kim Guehye G Moon Cheol C Kim Hyun Jung HJ Kim Tae Ho TH Jang Jichan J
PloS one 20180426 4
Mycobacterium abscessus is a rapidly growing life-threatening mycobacterium with multiple drug-resistance mechanisms. However, there is no official regimen for M. abscessus therapy. In this study, we screened the Pathogen Box, which contains 400 drug-like molecules active against neglected diseases, to identify active molecules targeting Mycobacterium abscessus using resazurin live/dead assays. In this screening assay, the Z-factor was 0.7, as an indicator of the statistical confidence of the as ...[more]