Ontology highlight
ABSTRACT:
SUBMITTER: Yang SR
PROVIDER: S-EPMC5919677 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Yang Su-Rong SR Hu Zhen-Zhen ZZ Luo Yan-Jia YJ Zhao Ya-Nan YN Sun Huan-Xin HX Yin Dou D Wang Chen-Yao CY Yan Yu-Dong YD Wang Dian-Ru DR Yuan Xiang-Shan XS Ye Chen-Bo CB Guo Wei W Qu Wei-Min WM Cherasse Yoan Y Lazarus Michael M Ding Yu-Qiang YQ Huang Zhi-Li ZL
PLoS biology 20180413 4
The rostromedial tegmental nucleus (RMTg), also called the GABAergic tail of the ventral tegmental area, projects to the midbrain dopaminergic system, dorsal raphe nucleus, locus coeruleus, and other regions. Whether the RMTg is involved in sleep-wake regulation is unknown. In the present study, pharmacogenetic activation of rat RMTg neurons promoted non-rapid eye movement (NREM) sleep with increased slow-wave activity (SWA). Conversely, rats after neurotoxic lesions of 8 or 16 days showed decre ...[more]