Ontology highlight
ABSTRACT:
SUBMITTER: Martin MP
PROVIDER: S-EPMC5919796 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Martin Maureen P MP Naranbhai Vivek V Shea Patrick R PR Qi Ying Y Ramsuran Veron V Vince Nicolas N Gao Xiaojiang X Thomas Rasmi R Brumme Zabrina L ZL Carlson Jonathan M JM Wolinsky Steven M SM Goedert James J JJ Walker Bruce D BD Segal Florencia P FP Deeks Steven G SG Haas David W DW Migueles Stephen A SA Connors Mark M Michael Nelson N Fellay Jacques J Gostick Emma E Llewellyn-Lacey Sian S Price David A DA Lafont Bernard A BA Pymm Phillip P Saunders Philippa M PM Widjaja Jacqueline J Wong Shu Cheng SC Vivian Julian P JP Rossjohn Jamie J Brooks Andrew G AG Carrington Mary M
The Journal of clinical investigation 20180403 5
HLA-B*57 control of HIV involves enhanced CD8+ T cell responses against infected cells, but extensive heterogeneity exists in the level of HIV control among B*57+ individuals. Using whole-genome sequencing of untreated B*57+ HIV-1-infected controllers and noncontrollers, we identified a single variant (rs643347A/G) encoding an isoleucine-to-valine substitution at position 47 (I47V) of the inhibitory killer cell immunoglobulin-like receptor KIR3DL1 as the only significant modifier of B*57 protect ...[more]