Coagulation Factor XII Levels and Intrinsic Thrombin Generation in Multiple Sclerosis.

ABSTRACT: Background:Factor XII (FXII) activation initiates the intrinsic (contact) coagulation pathway. It has been recently suggested that FXII could act as an autoimmunity mediator in multiple sclerosis (MS). FXII depositions nearby dentritic cells were detected in the central nervous system of MS patients and increased FXII activity has been reported in plasma of relapsing remitting and secondary progressive MS patients. FXII inhibition has been proposed to treat MS. Objective:To investigate in MS patients multiple FXII-related variables, including the circulating amount of protein, its pro-coagulant function, and their variation over time. To explore kinetic activation features of FXII in thrombin generation (TG). Methods:In plasma from 74 MS patients and 49 healthy subjects (HS), FXII procoagulant activity (FXII:c) and FXII protein (FXII:Ag) levels were assessed. Their ratio (FXII:ratio) values were derived. Intrinsic TG was evaluated by different triggers. Results:Higher FXII:Ag levels (p?=?0.003) and lower FXII:ratio (p?

SUBMITTER: Ziliotto N 

PROVIDER: S-EPMC5919941 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature