Ontology highlight
ABSTRACT:
SUBMITTER: Gnanapragasam MN
PROVIDER: S-EPMC5920080 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Gnanapragasam Merlin Nithya MN Crispino John D JD Ali Abdullah M AM Weinberg Rona R Hoffman Ronald R Raza Azra A Bieker James J JJ
Scientific reports 20180426 1
Erythroid Krüppel-like Factor (EKLF/KLF1) is an erythroid-enriched transcription factor that plays a global role in all aspects of erythropoiesis, including cell cycle control and differentiation. We queried whether its mutation might play a role in red cell malignancies by genomic sequencing of the KLF1 transcription unit in cell lines, erythroid neoplasms, dysplastic disorders, and leukemia. In addition, we queried published databases from a number of varied sources. In all cases we only found ...[more]