E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium.
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ABSTRACT:
SUBMITTER: Horne HN
PROVIDER: S-EPMC5920115 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium.
Horne Hisani N HN Oh Hannah H Sherman Mark E ME Palakal Maya M Hewitt Stephen M SM Schmidt Marjanka K MK Milne Roger L RL Hardisson David D Benitez Javier J Blomqvist Carl C Bolla Manjeet K MK Brenner Hermann H Chang-Claude Jenny J Cora Renata R Couch Fergus J FJ Cuk Katarina K Devilee Peter P Easton Douglas F DF Eccles Diana M DM Eilber Ursula U Hartikainen Jaana M JM Heikkilä Päivi P Holleczek Bernd B Hooning Maartje J MJ Jones Michael M Keeman Renske R Mannermaa Arto A Martens John W M JWM Muranen Taru A TA Nevanlinna Heli H Olson Janet E JE Orr Nick N Perez Jose I A JIA Pharoah Paul D P PDP Ruddy Kathryn J KJ Saum Kai-Uwe KU Schoemaker Minouk J MJ Seynaeve Caroline C Sironen Reijo R Smit Vincent T H B M VTHBM Swerdlow Anthony J AJ Tengström Maria M Thomas Abigail S AS Timmermans A Mieke AM Tollenaar Rob A E M RAEM Troester Melissa A MA van Asperen Christi J CJ van Deurzen Carolien H M CHM Van Leeuwen Flora F FF Van't Veer Laura J LJ García-Closas Montserrat M Figueroa Jonine D JD
Scientific reports 20180426 1
E-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E-cadherin tumor immunohistochemistry expression using tissue microarrays of 5,933 female invasive breast cancers from 12 studies from the Breast Cancer Consortium. H-scores were calculated and case-case odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression. Survival a ...[more]
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