Ontology highlight
ABSTRACT:
SUBMITTER: Espigol-Frigole G
PROVIDER: S-EPMC5920281 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Espígol-Frigolé Georgina G Planas-Rigol Ester E Lozano Ester E Corbera-Bellalta Marc M Terrades-García Nekane N Prieto-González Sergio S García-Martínez Ana A Hernández-Rodríguez Jose J Grau Josep M JM Cid Maria C MC
Frontiers in immunology 20180420
<h4>Background</h4>Giant-cell arteritis (GCA) is considered a T helper (Th)1- and Th17-mediated disease. Interleukin (IL)-12 is a heterodimeric cytokine (p35/p40) involved in Th1 differentiation. When combining with p19 subunit, p40 compose IL-23, a powerful pro-inflammatory cytokine that maintains Th17 response.<h4>Objectives</h4>The aims of this study were to investigate p40, p35, and p19 subunit expression in GCA lesions and their combinations to conform different cytokines, to assess the eff ...[more]