Ontology highlight
ABSTRACT:
SUBMITTER: Gies V
PROVIDER: S-EPMC5922279 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
JCI insight 20180308 5
B cells play a central role in systemic lupus erythematosus (SLE) pathophysiology but dysregulated pathways leading to a break in B cell tolerance remain unclear. Since Toll-like receptor 9 (TLR9) favors the elimination of autoreactive B cells in the periphery, we assessed TLR9 function in SLE by analyzing the responses of B cells and plasmacytoid dendritic cells (pDCs) isolated from healthy donors and patients after stimulation with CpG, a TLR9 agonist. We found that SLE B cells from patients w ...[more]