Ontology highlight
ABSTRACT:
SUBMITTER: Audrito V
PROVIDER: S-EPMC5922372 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Audrito Valentina V Managò Antonella A Zamporlini Federica F Rulli Eliana E Gaudino Federica F Madonna Gabriele G D'Atri Stefania S Antonini Cappellini Gian Carlo GC Ascierto Paolo Antonio PA Massi Daniela D Raffaelli Nadia N Mandalà Mario M Deaglio Silvia S
Oncotarget 20180410 27
Metastatic melanoma carrying BRAF mutations represent a still unmet medical need as success of BRAF inhibitors is limited by development of resistance. Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme in NAD biosynthesis. An extracellular form (eNAMPT) possesses cytokine-like functions and is up-regulated in inflammatory disorders, including cancer. Here we show that eNAMPT is actively released in culture supernatants of melanoma cell lines. Furthermore, cells that become resistant ...[more]