Dataset Information

Health-related quality of life in Chinese inpatients with lung cancer treatedin large general hospitals: across-sectional study.

ABSTRACT: OBJECTIVE:In China, psychosocial problems of patients with cancer are under-recognised and undertreated in medical oncology practice. This study examined the health-related quality of life (QOL) in inpatients with lung cancer treated in large general hospitals and explored the demographic, clinical and psychosocial factors associated with QOL. DESIGN:Cross-sectional study. PARTICIPANTS AND SETTING:Altogether, 148 inpatients with lung cancer were consecutively recruited from two large general hospitals in Tianjin, China. MAIN OUTCOME MEASURED:QOL, pain intensity, depressive and anxiety symptoms, and social support were assessed with WHO QOL Scale Brief Version, four-point Verbal Rating Scale, Hospital Anxiety and Depression Scale and Social Support Rating Scale, respectively. RESULTS:Compared with the normative data for the Chinese general population, patients had significantly lower scores in physical (t=-25.860, p<0.001) and psychological (t=-18.225, p<0.001) QOL. Being unmarried (?=-2.471, 95%?CI -4.908 to -0.034), poor economic status (?=-1.764, 95%?CI -2.964 to -0.564), cancer metastasis (?=-1.328, 95%?CI -2.632 to -0.024), poor performance status (?=-0.959, 95%?CI -1.542 to -0.376), depression (?=-0.465, 95%?CI -0.631 to -0.299), anxiety (?=-0.208, 95%?CI -0.354 to -0.062) and low utilisation of social support (?=-0.344, 95%?CI -0.577 to -0.111) were independently associated with poor physical QOL, while female gender (?=-1.494, 95%?CI -0.649 to -2.339), less education years (?=-0.209, 95%?CI -0.294 to -0.123), currently receiving chemotherapy (?=-1.536, 95%?CI -3.051 to -0.021), small-cell cancer (?=-1.157, 95%?CI -2.223 to -0.091), more intense pain (?=-0.535, 95%?CI -0.919 to -0.151), poor performance status (?=-0.930, 95%?CI -1.383 to -0.477), anxiety (?=-0.178, 95%?CI -0.248 to -0.108) and inadequate subjective social support (?=-0.137, 95%?CI -0.153 to -0.121) were independently associated with poor psychological QOL. CONCLUSIONS:Inpatients with lung cancer treated in Chinese large general hospitals have poorer QOL than the general population. Effective prevention and management of psychosocial problems are potentially effective to improve their QOL.

SUBMITTER: Gu W

PROVIDER: S-EPMC5922485 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Health-related quality of life in Chinese inpatients with lung cancer treatedin large general hospitals: across-sectional study.

Gu Wen W Xu Yan-Min YM Zhong Bao-Liang BL

BMJ open 20180424 4

<h4>Objective</h4>In China, psychosocial problems of patients with cancer are under-recognised and undertreated in medical oncology practice. This study examined the health-related quality of life (QOL) in inpatients with lung cancer treated in large general hospitals and explored the demographic, clinical and psychosocial factors associated with QOL.<h4>Design</h4>Cross-sectional study.<h4>Participants and setting</h4>Altogether, 148 inpatients with lung cancer were consecutively recruited from ...[more]

PMID: 29691245

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Project description:ObjectivesThe ways patients cope with advanced cancer can influence their health-related quality of life (HRQoL). This study aims to examine the mediating role of positive and negative mood in the relationship between coping and HRQoL in patients with advanced lung cancer.MethodsA consecutive sample of 261 patients (mean age: 59.99±9.53) diagnosed with stage III or IV lung cancer was recruited from the inpatient unit in a hospital that specialises in chest-related disease in Shanghai, China. Participants completed measurements including Medical Coping Modes Questionnaire, Positive and Negative Affect Schedule, and 5-level EuroQol 5-dimension instrument.ResultsAlthough the total effects of confrontation on HRQoL were not significant, competing indirect effects via mood were identified: (1) positive indirect effects through positive mood were found for confrontation on mobility, usual activities, pain/discomfort and overall utility index (indirect effect=0.01, 95% CI 0.003 to 0.03); (2) negative indirect effects through negative mood were found for confrontation on mobility, pain/discomfort, anxiety/depression and overall utility index (indirect effect=-0.01, 95% CI -0.03 to -0.001). Resigned acceptance was negatively associated with HRQoL, and indirect effects via mood were identified: (1) negative indirect effects through positive mood were found for resigned acceptance on mobility, self-care, usual activities, pain/discomfort and overall utility index (indirect effect=-0.01, 95% CI -0.03 to -0.003); (2) negative indirect effects through negative mood were found for resigned acceptance on domains of HRQoL and overall utility index (indirect effect=-0.04, 95% CI -0.06 to -0.02).ConclusionsConfronting advanced lung cancer can fuel ambivalent emotional experiences. Nevertheless, accepting the illness in a resigned way can be maladaptive for health outcomes. The findings suggest interventions that facilitate adaptive coping, reduce negative mood and enhance positive mood, as this could help to improve or maintain HRQoL in patients with advanced lung cancer.

Project description:Seafarers have reported impaired health and health-related quality of life (HRQOL). Social support might increase HRQOL, but little is known about this association among Chinese seafarers. The aim of this study was to describe social support and explore its association with HRQOL among Chinese seafarers.A cross-sectional survey was conducted in the ports of Nantong and Rugao, China, from April to December 2013. A total of 917 Chinese seafarers were interviewed on social support, mental distress, perceived occupational stress, and HRQOL using the following self-administered questionnaires: The Social Support Rating Scale, Self-rating Depression Scale, Occupational Stress Questionnaire, and the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire. Hierarchical linear regression modelling was used to analyze the association between seafarers' subjective level of social support and their HRQOL.Of the 917 male Chinese seafarers included in the study, 40.7% perceived high levels of social support, and 39.1% were highly satisfied with their overall quality of life (QOL). Hierarchical regression analysis showed significant associations between level of social support and all health dimensions in the WHOQOL-BREF, even after adjusting for depressive symptoms, occupational stress, occupational activities, sleep duration, and other relevant covariates. Compared with the medium or low level social support group, seafarers with a high level of social support had better QOL scores in the general facet health and QOL (? = 2.43, p<0.05), and the physical health (? = 3.23, p<0.001), psychological health (? = 5.56, p<0.001), social relation (? = 6.07, p<0.001), and environment domains (? = 4.27, p<0.001). In addition, depression, occupational stress, occupational activities, and sleep duration were found to be determinants of seafarers' HRQOL.Chinese seafarers have poorer HRQOL than the general population, but social support has a significant positive effect on their HRQOL. Efforts to improve social support should be undertaken.

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Health-related quality of life in Chinese inpatients with lung cancer treatedin large general hospitals: across-sectional study.

Publications

Health-related quality of life in Chinese inpatients with lung cancer treatedin large general hospitals: across-sectional study.

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