A biphasic dialytic strategy for the treatment of neonatal hyperammonemia.
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ABSTRACT:
SUBMITTER: Hanudel M
PROVIDER: S-EPMC5922760 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
A biphasic dialytic strategy for the treatment of neonatal hyperammonemia.
Hanudel Mark M Avasare Sonal S Tsai Eileen E Yadin Ora O Zaritsky Joshua J
Pediatric nephrology (Berlin, Germany) 20140201 2
<h4>Background</h4>Neonates with inborn errors of metabolism (IEM) often develop hyperammonemia which, if not corrected quickly, may result in poor neurologic outcomes. As pharmacologic therapy cannot rapidly lower ammonia levels, dialysis is frequently required. Both hemodialysis (HD) and standard-dose continuous renal replacement therapy (CRRT) are effective; however, HD may be followed by post-dialytic ammonia rebound, and standard-dose CRRT may not effect a rapid enough decrease in ammonia l ...[more]
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