Unknown

Dataset Information

0

Restorative effects of human neural stem cell grafts on the primate spinal cord.

ABSTRACT: We grafted human spinal cord-derived neural progenitor cells (NPCs) into sites of cervical spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug immunosuppression, grafts survived at least 9 months postinjury and expressed both neuronal and glial markers. Monkey axons regenerated into grafts and formed synapses. Hundreds of thousands of human axons extended out from grafts through monkey white matter and synapsed in distal gray matter. Grafts gradually matured over 9 months and improved forelimb function beginning several months after grafting. These findings in a 'preclinical trial' support translation of NPC graft therapy to humans with the objective of reconstituting both a neuronal and glial milieu in the site of spinal cord injury.

SUBMITTER: Rosenzweig ES 

PROVIDER: S-EPMC5922761 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

We grafted human spinal cord-derived neural progenitor cells (NPCs) into sites of cervical spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug immunosuppression, grafts survived at least 9 months postinjury and expressed both neuronal and glial markers. Monkey axons regenerated into grafts and formed synapses. Hundreds of thousands of human axons extended out from grafts through monkey white matter and synapsed in distal gray matter. Grafts gradually matured over 9 months and  ...[more]

Similar Datasets

Unknown Neural Stem Cell Grafts Form Extensive Synaptic Networks that Integrate with Host Circuits after Spinal Cord Injury.
| S-EPMC7484050 | biostudies-literature
Unknown Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: differentiation and structural integration into the segmental motor circuitry.
| S-EPMC2727711 | biostudies-literature
Unknown Safety of human neural stem cell transplantation in chronic spinal cord injury.
| S-EPMC3841091 | biostudies-literature
Unknown Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration.
| S-EPMC4860037 | biostudies-literature
Unknown Rehabilitation combined with neural progenitor cell grafts enables functional recovery in chronic spinal cord injury.
| S-EPMC9462483 | biostudies-literature
Unknown Insulin-like Growth Factor-1 Receptor Dictates Beneficial Effects of Treadmill Training by Regulating Survival and Migration of Neural Stem Cell Grafts in the Injured Spinal Cord.
| S-EPMC6318559 | biostudies-literature
Unknown 3D Printed Stem-Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds.
| S-EPMC7319181 | biostudies-literature
Unknown Increasing Human Neural Stem Cell Transplantation Dose Alters Oligodendroglial and Neuronal Differentiation after Spinal Cord Injury.
| S-EPMC5469937 | biostudies-literature
Unknown Restorative functions of Autologous Stem Leydig Cell transplantation in a Testosterone-deficient non-human primate model.
| S-EPMC7392013 | biostudies-literature
Unknown Endothelial and Astrocytic Support by Human Bone Marrow Stem Cell Grafts into Symptomatic ALS Mice towards Blood-Spinal Cord Barrier Repair.
| S-EPMC5429840 | biostudies-literature