Ontology highlight
ABSTRACT:
SUBMITTER: Rosenzweig ES
PROVIDER: S-EPMC5922761 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Nature medicine 20180226 4
We grafted human spinal cord-derived neural progenitor cells (NPCs) into sites of cervical spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug immunosuppression, grafts survived at least 9 months postinjury and expressed both neuronal and glial markers. Monkey axons regenerated into grafts and formed synapses. Hundreds of thousands of human axons extended out from grafts through monkey white matter and synapsed in distal gray matter. Grafts gradually matured over 9 months and ...[more]