Ontology highlight
ABSTRACT:
SUBMITTER: Lu Z
PROVIDER: S-EPMC5923094 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Lu Zhongyi Z Jia Xiaodong X Chen Yong Y Han Xuelin X Chen Fangyan F Tian Shuguang S Su Xueting X Li Zongwei Z Zhao Jingya J Zhang Xi X Hu Mandong M Huang Liuyu L Han Li L
Antimicrobial agents and chemotherapy 20180426 5
Through some specific amino acid residues, cofilin, a ubiquitous actin depolymerization factor, can significantly affect mitochondrial function related to drug resistance and apoptosis in <i>Saccharomyces cerevisiae</i>; however, this modulation in a major fungal pathogen, <i>Aspergillus fumigatus</i>, was still unclear. Hereby, it was found, first, that mutations on several charged residues in cofilin to alanine, D19A-R21A, E48A, and K36A, increased the formation of reactive oxygen species and ...[more]