Effect of Antimicrobial Agents on Inflammatory Cytokines in Acute Leptospirosis.
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ABSTRACT:
SUBMITTER: Fernando N
PROVIDER: S-EPMC5923126 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Effect of Antimicrobial Agents on Inflammatory Cytokines in Acute Leptospirosis.
Fernando Narmada N de Silva Rajiva R Handunnetti Shiroma M SM Karunanayake Lilani L De Silva Nipun Lakshitha NL de Silva H Janaka HJ Rajapakse Senaka S Premawansa Sunil S
Antimicrobial agents and chemotherapy 20180426 5
The aim of this study was to assess the inflammatory cytokine response and possible association with antimicrobial treatment with penicillin, ceftriaxone, and doxycycline in acute leptospirosis. In the early acute stage, interleukin-10 (IL-10) levels were higher in mild cases than in severe cases (<i>P</i> = 0.01). IL-6 and IL-8 levels were low in patients who received >5 antimicrobial doses (<i>P</i> < 0.01). IL-8 levels were negatively correlated with the number of ceftriaxone doses administer ...[more]
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