Ontology highlight
ABSTRACT:
SUBMITTER: Craver BM
PROVIDER: S-EPMC5923359 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Craver Brianna M BM El Alaoui Kenza K Scherber Robyn M RM Fleischman Angela G AG
Cancers 20180403 4
Hematopoietic stem cells (HSCs) maintain an organism's immune system for a lifetime, and derangements in HSC proliferation and differentiation result in hematologic malignancies. Chronic inflammation plays a contributory if not causal role in HSC dysfunction. Inflammation induces HSC exhaustion, which promotes the emergence of mutant clones that may be resistant to an inflammatory microenvironment; this likely promotes the onset of a myeloid hematologic malignancy. Inflammatory cytokines are cha ...[more]