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New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54.

ABSTRACT: Four new eudesmane-type sesquiterpenoids, penicieudesmol A-D (1-4), were isolated from the fermentation broth of the mangrove-derived endophytic fungus Penicillium sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher's method. The bioassays results showed that 2 exhibited weak cytotoxicity against K-562 cells.

SUBMITTER: Qiu L

PROVIDER: S-EPMC5923395 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54.

Qiu Liuming L Wang Pei P Liao Ge G Zeng Yanbo Y Cai Caihong C Kong Fandong F Guo Zhikai Z Proksch Peter P Dai Haofu H Mei Wenli W

Marine drugs 20180328 4

Four new eudesmane-type sesquiterpenoids, penicieudesmol A-D (1-4), were isolated from the fermentation broth of the mangrove-derived endophytic fungus Penicillium sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher's method. The bioassays results showed that 2 exhibited weak cytotoxicity against K-562 cells. ...[more]

PMID: 29597304

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