Feline APOBEC3s, Barriers to Cross-Species Transmission of FIV?
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ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC5923480 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Feline APOBEC3s, Barriers to Cross-Species Transmission of FIV?
Zhang Zeli Z Gu Qinyong Q Marino Daniela D Lee Kyeong-Lim KL Kong Il-Keun IK Häussinger Dieter D Münk Carsten C
Viruses 20180410 4
The replication of lentiviruses highly depends on host cellular factors, which defines their species-specific tropism. Cellular restriction factors that can inhibit lentiviral replication were recently identified. <i>Feline immunodeficiency virus</i> (FIV) was found to be sensitive to several feline cellular restriction factors, such as apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3 (APOBEC3) and tetherin, but FIV evolved to counteract them. Here, we describe the molecular me ...[more]
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