Ontology highlight
ABSTRACT:
SUBMITTER: Sprague WS
PROVIDER: S-EPMC5923504 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Sprague Wendy S WS Troyer Ryan M RM Zheng Xin X Wood Britta A BA Macmillian Martha M Carver Scott S VandeWoude Susan S
Viruses 20180420 4
We previously showed that cats that were infected with non-pathogenic Puma lentivirus (PLV) and then infected with pathogenic feline immunodeficiency virus (FIV) (co-infection with the host adapted/pathogenic virus) had delayed FIV proviral and RNA viral loads in blood, with viral set-points that were lower than cats infected solely with FIV. This difference was associated with global CD4⁺ T cell preservation, greater interferon gamma (IFN-γ) mRNA expression, and no cytotoxic T lymphocyte ...[more]