Ontology highlight
ABSTRACT:
SUBMITTER: Huang J
PROVIDER: S-EPMC5923877 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Huang Jing J Polgár Erika E Solinski Hans Jürgen HJ Mishra Santosh K SK Tseng Pang-Yen PY Iwagaki Noboru N Boyle Kieran A KA Dickie Allen C AC Kriegbaum Mette C MC Wildner Hendrik H Zeilhofer Hanns Ulrich HU Watanabe Masahiko M Riddell John S JS Todd Andrew J AJ Hoon Mark A MA
Nature neuroscience 20180319 5
Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the contribution of the neuropeptide somatostatin. We find that in the periphery, somatostatin is exclusively expressed in Nppb<sup>+</sup> neurons, and we demonstrate that Nppb<sup>+</sup>somatostatin<sup>+</sup> cell ...[more]