Multimodal neuroimaging and behavioral assessment of ?-synuclein polymorphism rs356219 in older adults.
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ABSTRACT:
SUBMITTER: Burciu RG
PROVIDER: S-EPMC5924640 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
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Multimodal neuroimaging and behavioral assessment of α-synuclein polymorphism rs356219 in older adults.
Burciu Roxana G RG Seidler Rachael D RD Shukla Priyank P Nalls Mike A MA Singleton Andrew B AB Okun Michael S MS Vaillancourt David E DE
Neurobiology of aging 20180210
The single-nucleotide polymorphism rs356219 in the α-synuclein (SNCA) gene has been shown to significantly contribute to an earlier age at onset of Parkinson's disease (PD), and regulates SNCA expression in PD brain regions, blood, and plasma. Here, we used multimodal magnetic resonance imaging (MRI) to study healthy adults with and without the rs356219 risk genotype. Motor and cognitive tests were administered, and all participants underwent functional and structural MRI. Imaging analyses inclu ...[more]
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