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Targeting Head and Neck Cancer by Vaccination.


ABSTRACT: Head and neck cancer (HNC) is a heterogeneous group of squamous cell cancers that affect the oral cavity, pharynx, and larynx. Worldwide, it is the sixth most common cancer but in parts of Southern and South-East Asia, HNC is one of the most common cancers. A significant proportion of HNC is driven by human papillomavirus (HPV) infection, whereas HPV-independent HNC is associated with alcohol, smoking, and smokeless tobacco consumption. Here, we review the past and present experience of targeting HNC with vaccination focusing on HPV-derived antigens as well as non-viral antigens for HPV-negative HNC. Novel therapeutic approaches for HNC will focus not only on effective vaccine platforms but will also target the stroma-rich immunosuppressive microenvironment found in those tumours.

SUBMITTER: Wang C 

PROVIDER: S-EPMC5924779 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Targeting Head and Neck Cancer by Vaccination.

Wang Chuan C   Dickie James J   Sutavani Ruhcha V RV   Pointer Catherine C   Thomas Gareth J GJ   Savelyeva Natalia N  

Frontiers in immunology 20180423


Head and neck cancer (HNC) is a heterogeneous group of squamous cell cancers that affect the oral cavity, pharynx, and larynx. Worldwide, it is the sixth most common cancer but in parts of Southern and South-East Asia, HNC is one of the most common cancers. A significant proportion of HNC is driven by human papillomavirus (HPV) infection, whereas HPV-independent HNC is associated with alcohol, smoking, and smokeless tobacco consumption. Here, we review the past and present experience of targetin  ...[more]

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