Ontology highlight
ABSTRACT:
SUBMITTER: Gong L
PROVIDER: S-EPMC5924883 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Gong Lili L Liu Fangyuan F Xiong Zhen Z Qi Ruili R Luo Zhongwen Z Gong Xiaodong X Nie Qian Q Sun Qian Q Liu Yun-Fei YF Qing Wenjie W Wang Ling L Zhang Lan L Tang Xiangcheng X Huang Shan S Huang Shan S Li Gen G Ouyang Hong H Xiang Mengqing M Nguyen Quan Dong QD Liu Yizhi Y Li David Wan-Cheng DW
Proceedings of the National Academy of Sciences of the United States of America 20180405 17
Oxidative stress (OS)-induced retinal pigment epithelium (RPE) cell apoptosis is critically implicated in the pathogenesis of age-related macular degeneration (AMD), a leading cause of blindness in the elderly. Heterochromatin, a compact and transcriptional inert chromatin structure, has been recently shown to be dynamically regulated in response to stress stimuli. The functional mechanism of heterochromatin on OS exposure is unclear, however. Here we show that OS increases heterochromatin forma ...[more]