Dataset Information

Computational Approach to Investigating Key GO Terms and KEGG Pathways Associated with CNV.

ABSTRACT: Choroidal neovascularization (CNV) is a severe eye disease that leads to blindness, especially in the elderly population. Various endogenous and exogenous regulatory factors promote its pathogenesis. However, the detailed molecular biological mechanisms of CNV have not been fully revealed. In this study, by using advanced computational tools, a number of key gene ontology (GO) terms and KEGG pathways were selected for CNV. A total of 29 validated genes associated with CNV and 17,639 nonvalidated genes were encoded based on the features derived from the GO terms and KEGG pathways by using the enrichment theory. The widely accepted feature selection method-maximum relevance and minimum redundancy (mRMR)-was applied to analyze and rank the features. An extensive literature review for the top 45 ranking features was conducted to confirm their close associations with CNV. Identifying the molecular biological mechanisms of CNV as described by the GO terms and KEGG pathways may contribute to improving the understanding of the pathogenesis of CNV.

SUBMITTER: Luo Y

PROVIDER: S-EPMC5925134 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Computational Approach to Investigating Key GO Terms and KEGG Pathways Associated with CNV.

Luo YuanYuan Y Yan Yan Y Zhang Shiqi S Li Zhen Z

BioMed research international 20180411

Choroidal neovascularization (CNV) is a severe eye disease that leads to blindness, especially in the elderly population. Various endogenous and exogenous regulatory factors promote its pathogenesis. However, the detailed molecular biological mechanisms of CNV have not been fully revealed. In this study, by using advanced computational tools, a number of key gene ontology (GO) terms and KEGG pathways were selected for CNV. A total of 29 validated genes associated with CNV and 17,639 nonvalidated ...[more]

PMID: 29850576

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Dataset Information

Computational Approach to Investigating Key GO Terms and KEGG Pathways Associated with CNV.

Publications

Computational Approach to Investigating Key GO Terms and KEGG Pathways Associated with CNV.

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