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Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma.

ABSTRACT: In order to clarify regions of production and to discriminate processing methods, quantitative and qualitative analyses for saccharides and terpenes in 35 batches of Alismatis Rhizoma were performed. Methodologies included HPLC-PDA, HPLC-VWD and UHPLC-MS n , combined with principal component analysis (PCA) and partial least squares regression techniques (PLSR). The inhibitory effects of triterpenes and Alismatis Rhizoma extracts on lipase activity were evaluated in vitro. PLSR analysis revealed significant positive correlations (R2 = 0.5795) between the contents of triterpenes 10, 14, 15, 18 and 22 and the inhibitory effects of Alismatis Rhizoma. The present study establishes an effective method for simultaneous determination of multiple components, and identifies key bioactive triterpenes. These results can be used for systematic and novel analytical strategies for the quality control of Alismatis Rhizoma production.

SUBMITTER: Gao X

PROVIDER: S-EPMC5925412 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma.

Gao Xiaoxv X Sun Chengpeng C Yu Zhenglong Z Cang Jian J Tian Xiangge X Huo Xiaokui X Feng Lei L Liu Xinguang X Wang Chao C Zhang Baojing B Ma Xiaochi X

Acta pharmaceutica Sinica. B 20170930 2

In order to clarify regions of production and to discriminate processing methods, quantitative and qualitative analyses for saccharides and terpenes in 35 batches of Alismatis Rhizoma were performed. Methodologies included HPLC-PDA, HPLC-VWD and UHPLC-MS n , combined with principal component analysis (PCA) and partial least squares regression techniques (PLSR). The inhibitory effects of triterpenes and Alismatis Rhizoma extracts on lipase activity were evaluated in vitro ...[more]

PMID: 29719785

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Dataset Information

Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma.

Publications

Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma.

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