Ontology highlight
ABSTRACT:
SUBMITTER: Ng PK
PROVIDER: S-EPMC5926201 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Cancer cell 20180301 3
The functional impact of the vast majority of cancer somatic mutations remains unknown, representing a critical knowledge gap for implementing precision oncology. Here, we report the development of a moderate-throughput functional genomic platform consisting of efficient mutant generation, sensitive viability assays using two growth factor-dependent cell models, and functional proteomic profiling of signaling effects for select aberrations. We apply the platform to annotate >1,000 genomic aberra ...[more]