Intravoxel incoherent motion (IVIM) and non-Gaussian diffusion MRI of the lactating breast.

ABSTRACT:

Purpose

To investigate the effect of breastfeeding on IVIM and non-Gaussian diffusion MRI in the breast.

Materials and methods

An IRB approved prospective study enrolled seventeen volunteers (12 in lactation and 5 with post-weaning, range 31-43 years; mean 35.4 years). IVIM (f_IVIM and D*) and non-Gaussian diffusion (ADC₀ and K) parameters using 16 b values, plus synthetic apparent diffusion coefficients (sADCs) from 2 key b values (b = 200 and 1500 s/mm²) were calculated using regions of interest. ADC₀ maps of the whole breast were generated and their contrast patterns were evaluated by two independent readers using retroareolar and segmental semi-quantitative scores. To compare the diffusion and IVIM parameters, Wilcoxon signed ra

SUBMITTER: Iima M 

PROVIDER: S-EPMC5926247 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature