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Self-assembly of random co-polymers for selective binding and detection of peptides.

ABSTRACT: Amphiphilic random co-polymers, which form stable reverse micelle-type assemblies, have been designed and synthesized. We demonstrate that the reverse micelles, formed by these co-polymers are capable of selectively binding peptides through electrostatic interactions, indicating that these random polymers can self-organize into functionally selective materials. Moreover, these random co-polymers also enable the ordered co-crystallization of matrix and extracted guest molecules, giving rise to substantial signal enhancements during MALDI-MS detection. Together, these observations represent an excellent example of how random polymers can self-assemble into ordered, functional materials.

SUBMITTER: Zhao B

PROVIDER: S-EPMC5926817 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Self-assembly of random co-polymers for selective binding and detection of peptides.

Zhao Bo B Serrano Mahalia A C MAC Gao Jingjing J Zhuang Jiaming J Vachet Richard W RW Thayumanavan S S

Polymer chemistry 20171219 9

Amphiphilic random co-polymers, which form stable reverse micelle-type assemblies, have been designed and synthesized. We demonstrate that the reverse micelles, formed by these co-polymers are capable of selectively binding peptides through electrostatic interactions, indicating that these random polymers can self-organize into functionally selective materials. Moreover, these random co-polymers also enable the ordered co-crystallization of matrix and extracted guest molecules, giving rise to su ...[more]

PMID: 29725358

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