Ontology highlight
ABSTRACT:
SUBMITTER: Pastor WA
PROVIDER: S-EPMC5926822 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Nature cell biology 20180425 5
Naive and primed pluripotent human embryonic stem cells bear transcriptional similarity to pre- and post-implantation epiblast and thus constitute a developmental model for understanding the pluripotent stages in human embryo development. To identify new transcription factors that differentially regulate the unique pluripotent stages, we mapped open chromatin using ATAC-seq and found enrichment of the activator protein-2 (AP2) transcription factor binding motif at naive-specific open chromatin. ...[more]