Ontology highlight
ABSTRACT:
SUBMITTER: Schrum JE
PROVIDER: S-EPMC5927587 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Schrum Jacob E JE Crabtree Juliet N JN Dobbs Katherine R KR Kiritsy Michael C MC Reed George W GW Gazzinelli Ricardo T RT Netea Mihai G MG Kazura James W JW Dent Arlene E AE Fitzgerald Katherine A KA Golenbock Douglas T DT
Journal of immunology (Baltimore, Md. : 1950) 20180112 4
Malarial infection in naive individuals induces a robust innate immune response. In the recently described model of innate immune memory, an initial stimulus primes the innate immune system to either hyperrespond (termed training) or hyporespond (tolerance) to subsequent immune challenge. Previous work in both mice and humans demonstrated that infection with malaria can both serve as a priming stimulus and promote tolerance to subsequent infection. In this study, we demonstrate that initial stim ...[more]