Ontology highlight
ABSTRACT:
SUBMITTER: Xie J
PROVIDER: S-EPMC5928120 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Xie Jia J Gurler Main Hilal H Sacks Joelle D JD Muralidhar Goda G GG Barbolina Maria V MV
Oncogenesis 20180501 4
Failure of currently used cytotoxic chemotherapy is one of the main reasons behind high mortality from metastatic high grade serous ovarian carcinoma. We found that high expression of a receptor for fractalkine (CX<sub>3</sub>CR1) significantly correlated with shorter survival of patients with serous ovarian carcinoma treated with cytotoxic DNA damage chemotherapies, and reduction of CX<sub>3</sub>CR1 expression resulted in sensitization to several DNA damaging modalities, including x-ray radiat ...[more]