Ontology highlight
ABSTRACT:
SUBMITTER: Liu D
PROVIDER: S-EPMC5928165 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Nature communications 20180430 1
Chemoresistance is a major unmet clinical obstacle in ovarian cancer treatment. Epigenetics plays a pivotal role in regulating the malignant phenotype, and has the potential in developing therapeutically valuable targets that improve the dismal outcome of this disease. Here we show that a series of transcription factors, including C/EBPβ, GCM1, and GATA1, could act as potential modulators of histone methylation in tumor cells. Of note, C/EBPβ, an independent prognostic factor for patients with o ...[more]