C/EBP? enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation.
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ABSTRACT:
SUBMITTER: Liu D
PROVIDER: S-EPMC5928165 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation.
Liu Dan D Zhang Xiao-Xue XX Li Meng-Chen MC Cao Can-Hui CH Wan Dong-Yi DY Xi Bi-Xin BX Tan Jia-Hong JH Wang Ji J Yang Zong-Yuan ZY Feng Xin-Xia XX Ye Fei F Chen Gang G Wu Peng P Xi Ling L Wang Hui H Zhou Jian-Feng JF Feng Zuo-Hua ZH Ma Ding D Gao Qing-Lei QL
Nature communications 20180430 1
Chemoresistance is a major unmet clinical obstacle in ovarian cancer treatment. Epigenetics plays a pivotal role in regulating the malignant phenotype, and has the potential in developing therapeutically valuable targets that improve the dismal outcome of this disease. Here we show that a series of transcription factors, including C/EBPβ, GCM1, and GATA1, could act as potential modulators of histone methylation in tumor cells. Of note, C/EBPβ, an independent prognostic factor for patients with o ...[more]
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