Endothelial Activation: The Ang/Tie Axis in Sepsis.
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ABSTRACT:
SUBMITTER: Leligdowicz A
PROVIDER: S-EPMC5928262 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Endothelial Activation: The Ang/Tie Axis in Sepsis.
Leligdowicz Aleksandra A Richard-Greenblatt Melissa M Wright Julie J Crowley Valerie M VM Kain Kevin C KC
Frontiers in immunology 20180424
Sepsis, a dysregulated host response to infection that causes life-threatening organ dysfunction, is a highly heterogeneous syndrome with no specific treatment. Although sepsis can be caused by a wide variety of pathogenic organisms, endothelial dysfunction leading to vascular leak is a common mechanism of injury that contributes to the morbidity and mortality associated with the syndrome. Perturbations to the angiopoietin (Ang)/Tie2 axis cause endothelial cell activation and contribute to the p ...[more]
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