Ontology highlight
ABSTRACT:
SUBMITTER: Morgan SB
PROVIDER: S-EPMC5928291 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Morgan Sophie B SB Holzer Barbara B Hemmink Johanneke D JD Salguero Francisco J FJ Schwartz John C JC Agatic Gloria G Cameroni Elisabetta E Guarino Barbara B Porter Emily E Rijal Pramila P Townsend Alain A Charleston Bryan B Corti Davide D Tchilian Elma E
Frontiers in immunology 20180424
Influenza virus infection is a significant global health threat. Because of the lack of cross-protective universal vaccines, short time window during which antivirals are effective and drug resistance, new therapeutic anti-influenza strategies are required. Broadly, cross-protective antibodies that target conserved sites in the hemagglutinin (HA) stem region have been proposed as therapeutic agents. FI6 is the first proven such monoclonal antibody to bind to H1-H16 and is protective in mice and ...[more]