Ontology highlight
ABSTRACT:
SUBMITTER: Tu CY
PROVIDER: S-EPMC5928373 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Tu Chih-Yen CY Cheng Fang-Ju FJ Chen Chuan-Mu CM Wang Shu-Ling SL Hsiao Yu-Chun YC Chen Chia-Hung CH Hsia Te-Chun TC He Yu-Hao YH Wang Bo-Wei BW Hsieh I-Shan IS Yeh Yi-Lun YL Tang Chih-Hsin CH Chen Yun-Ju YJ Huang Wei-Chien WC
Molecular oncology 20180414 5
Cigarette smoking is one of the leading risks for lung cancer and is associated with the insensitivity of non-small cell lung cancer (NSCLC) to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). However, it remains undetermined whether and how cigarette smoke affects the therapeutic efficacy of EGFR TKIs. In this study, our data showed that chronic exposure to cigarette smoke extract (CSE) or tobacco smoke-derived carcinogen benzo[α]pyrene, B[α]P, but not nicotine-derived ...[more]