Large inter- and intra-case variability of first generation tau PET ligand binding in neurodegenerative dementias.

ABSTRACT: Imaging of pathological tau with positron emission tomography (PET) has the potential to allow early diagnosis of the dementias and monitoring of disease progression, including assessment of therapeutic interventions, in vivo. The first generation of tau PET tracers, including the carbazole flortaucipir and the 2-arylquinolines of the THK series, are now used in clinical research; however, concerns have been raised about off-target binding and low sensitivity.With the aim to determine the nature of tau pathology depicted by structurally distinct tau ligands we carried out a microscopic neuropathological evaluation in post-mortem human brain tissue of cases with primary and secondary tauopathies. Carbazole and 2-arylquinoline binding was only observed in cases with Alzheimer's disease and o

SUBMITTER: Wren MC 

PROVIDER: S-EPMC5928586 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature