Extracellular DNA and lipoteichoic acids interact with exopolysaccharides in the extracellular matrix of Streptococcus mutans biofilms.
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ABSTRACT:
SUBMITTER: Castillo Pedraza MC
PROVIDER: S-EPMC5929139 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
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Extracellular DNA and lipoteichoic acids interact with exopolysaccharides in the extracellular matrix of Streptococcus mutans biofilms.
Castillo Pedraza Midian C MC Novais Tatiana F TF Faustoferri Roberta C RC Quivey Robert G RG Terekhov Anton A Hamaker Bruce R BR Klein Marlise I MI
Biofouling 20170925 9
Streptococcus mutans-derived exopolysaccharides are virulence determinants in the matrix of biofilms that cause caries. Extracellular DNA (eDNA) and lipoteichoic acid (LTA) are found in cariogenic biofilms, but their functions are unclear. Therefore, strains of S. mutans carrying single deletions that would modulate matrix components were used: eDNA - ∆lytS and ∆lytT; LTA - ∆dltA and ∆dltD; and insoluble exopolysaccharide - ΔgtfB. Single-species (parental strain S. mutans UA159 or individual mut ...[more]
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