Ontology highlight
ABSTRACT:
SUBMITTER: Tiwary P
PROVIDER: S-EPMC5929172 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Tiwary Puja P Kumar Dinesh D Sundar Shyam S
The American journal of tropical medicine and hygiene 20171221 2
Miltefosine is the only orally administrable drug for the treatment of leishmaniasis. But in recent years, a decline in its efficacy points toward the emergence of resistance to this drug. Knowledge of biomarkers for miltefosine resistance may be beneficial for proper selection of treatment regimen. Splenic aspirates were collected and parasites cultured from patients relapsed after initial cure (<i>N</i> = 15) and successfully treated (<i>N</i> = 15) with miltefosine. Differential expression of ...[more]