Ontology highlight
ABSTRACT:
SUBMITTER: Miller IC
PROVIDER: S-EPMC5929470 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Miller Ian C IC Gamboa Castro Marielena M Maenza Joe J Weis Jason P JP Kwong Gabriel A GA
ACS synthetic biology 20180410 4
Engineered T cells are transforming broad fields in biomedicine, yet our ability to control cellular activity at specific anatomical sites remains limited. Here we engineer thermal gene switches to allow spatial and remote control of transcriptional activity using pulses of heat. These gene switches are constructed from the heat shock protein HSP70B' (HSPA6) promoter, show negligible basal transcriptional activity, and activate within an elevated temperature window of 40-45 °C. Using engineered ...[more]