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Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: A nested case-control study.


ABSTRACT: The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjusted for matching factors and other potential confounders. Our results showed that pancreatic cancer risk was neither associated with H. pylori seropositivity (OR?=?0.96; 95% CI: 0.70, 1.31) nor CagA seropositivity (OR?=?1.07; 95% CI: 0.77, 1.48). We also did not find any excess risk among individuals seropositive for H. pylori but seronegative for CagA, compared with the group seronegative for both antibodies (OR?=?0.94; 95% CI: 0.63, 1.38). However, we found that chronic corpus atrophic gastritis was non-significantly associated with an increased pancreatic cancer risk (OR?=?1.35; 95% CI: 0.77, 2.37), and although based on small numbers, the excess risk was particularly marked among individuals seronegative for both H. pylori and CagA (OR?=?5.66; 95% CI: 1.59, 20.19, p value for interaction?

SUBMITTER: Huang J 

PROVIDER: S-EPMC5930360 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: A nested case-control study.

Huang Jiaqi J   Zagai Ulrika U   Hallmans Göran G   Nyrén Olof O   Engstrand Lars L   Stolzenberg-Solomon Rachael R   Duell Eric J EJ   Overvad Kim K   Katzke Verena A VA   Kaaks Rudolf R   Jenab Mazda M   Park Jin Young JY   Murillo Raul R   Trichopoulou Antonia A   Lagiou Pagona P   Bamia Christina C   Bradbury Kathryn E KE   Riboli Elio E   Aune Dagfinn D   Tsilidis Konstantinos K KK   Capellá Gabriel G   Agudo Antonio A   Krogh Vittorio V   Palli Domenico D   Panico Salvatore S   Weiderpass Elisabete E   Tjønneland Anne A   Olsen Anja A   Martínez Begoña B   Redondo-Sanchez Daniel D   Chirlaque Maria-Dolores MD   Hm Peeters Petra P   Regnér Sara S   Lindkvist Björn B   Naccarati Alessio A   Ardanaz Eva E   Larrañaga Nerea N   Boutron-Ruault Marie-Christine MC   Rebours Vinciane V   Barré Amélie A   Bueno-de-Mesquita H B As HB   Ye Weimin W  

International journal of cancer 20170401 8


The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to  ...[more]

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