Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC5930403 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Li Zhihuan Z Lai Zon Weng ZW Christiano Romain R Gazos-Lopes Felipe F Walther Tobias C TC Farese Robert V RV
Molecular & cellular proteomics : MCP 20180205 5
Obesity is tightly linked to hepatic steatosis and insulin resistance. One feature of this association is the paradox of selective insulin resistance: insulin fails to suppress hepatic gluconeogenesis but activates lipid synthesis in the liver. How lipid accumulation interferes selectively with some branches of hepatic insulin signaling is not well understood. Here we provide a resource, based on unbiased approaches and established in a simple cell culture system, to enable investigations of the ...[more]