Ontology highlight
ABSTRACT:
SUBMITTER: McKown AC
PROVIDER: S-EPMC5930668 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
McKown Andrew C AC Semler Matthew W MW Rice Todd W TW
Critical care (London, England) 20180502 1
Determining the optimal positive end-expiratory pressure (PEEP) in patients with acute respiratory distress syndrome remains an area of active investigation. Most trials individualizing PEEP optimize one physiologic parameter (e.g., driving pressure) by titrating PEEP while holding other ventilator settings constant. Optimal PEEP, however, may depend on the tidal volume, and changing the tidal volume with which a best PEEP trial is performed may lead to different best PEEP settings in the same p ...[more]