Analysis of the role of rs2031920 and rs3813867 polymorphisms within the cytochrome P450 2E1 gene in the risk of squamous cell carcinoma.

ABSTRACT:

Background

To explore the genetic effect of rs2031920 and rs3813867 polymorphisms within the cytochrome P450 2E1 (CYP2E1) gene on the risk of squamous cell carcinoma (SCC), a meta-analysis was performed.

Methods

The eligible case-control studies were obtained by database searching and screening, and the specific statistical analysis was performed with STATA 12.0 software.

Results

After the process of database searching and screening, a total of 32 case-control studies with 7435 cases and 10,466 controls were ultimately included in our meta-analysis. With regard to the rs2031920 C/T polymorphism, in comparison to controls, a reduced risk in cases of esophageal squamous cell carcinoma (ESCC) was detected for the models of allele T vs. allele C [P = 0.025,

SUBMITTER: Zhang H 

PROVIDER: S-EPMC5930765 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature