Analysis of the role of rs2031920 and rs3813867 polymorphisms within the cytochrome P450 2E1 gene in the risk of squamous cell carcinoma.

ABSTRACT: Background:To explore the genetic effect of rs2031920 and rs3813867 polymorphisms within the cytochrome P450 2E1 (CYP2E1) gene on the risk of squamous cell carcinoma (SCC), a meta-analysis was performed. Methods:The eligible case-control studies were obtained by database searching and screening, and the specific statistical analysis was performed with STATA 12.0 software. Results:After the process of database searching and screening, a total of 32 case-control studies with 7435 cases and 10,466 controls were ultimately included in our meta-analysis. With regard to the rs2031920 C/T polymorphism, in comparison to controls, a reduced risk in cases of esophageal squamous cell carcinoma (ESCC) was detected for the models of allele T vs. allele C [P?=?0.025, odds ratio (OR)?=?0.67], carrier T vs. carrier C (P?=?0.014, OR?=?0.70), TT vs. CC (P?=?0.029, OR?=?0.65), CT vs. CC (P?=?0.040, OR?=?0.56), CT?+?TT vs. CC (P?=?0.035, OR?=?0.58). Similarly, a decreased SCC risk was observed for the rs3813867 G/C polymorphism in the allele, carrier, homozygote, dominant, and recessive models of overall SCC meta-analysis and "ESCC" subgroup analysis (all P?

SUBMITTER: Zhang H 

PROVIDER: S-EPMC5930765 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature