Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes.
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ABSTRACT: Background
Mediator complex (MED) proteins have a key role in transcriptional regulation, some interacting with the oestrogen receptor (ER). Interrogation of the METABRIC cohort suggested that MED7 may regulate lymphovascular invasion (LVI). Thus MED7 expression was assessed in large breast cancer (BC) cohorts to determine clinicopathological significance.Methods
MED7 gene expression was investigated in the METABRIC cohort (n?=?1980) and externally validated using bc-GenExMiner v4.0. Immunohistochemical expression was assessed in the Nottingham primary BC series (n?=?1280). Associations with clinicopathological variables and patient outcome were evaluated.Results
High MED7 mRNA and protein expression was associated with good prognostic factors: low grade, smaller tumour size, good NPI, positive hormone receptor status (p?ConclusionsMED7 is an important prognostic marker in BC, particularly in ER+luminal subtypes, associated with improved survival and warrants future functional analysis.
SUBMITTER: Joseph C
PROVIDER: S-EPMC5931067 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes.
Joseph Chitra C Macnamara Olivia O Craze Madeleine M Russell Roslin R Provenzano Elena E Nolan Christopher C CC Diez-Rodriguez Maria M Sonbul Sultan N SN Aleskandarany Mohammed A MA Green Andrew R AR Rakha Emad A EA Ellis Ian O IO Mukherjee Abhik A
British journal of cancer 20180328 8
<h4>Background</h4>Mediator complex (MED) proteins have a key role in transcriptional regulation, some interacting with the oestrogen receptor (ER). Interrogation of the METABRIC cohort suggested that MED7 may regulate lymphovascular invasion (LVI). Thus MED7 expression was assessed in large breast cancer (BC) cohorts to determine clinicopathological significance.<h4>Methods</h4>MED7 gene expression was investigated in the METABRIC cohort (n = 1980) and externally validated using bc-GenExMiner v ...[more]
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