Ontology highlight
ABSTRACT:
SUBMITTER: Yin J
PROVIDER: S-EPMC5931527 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Yin Jie J Yang Lele L Xie Yangli Y Liu Yan Y Li Sheng S Yang Wenjun W Xu Bo B Ji Hongbin H Ding Lianghua L Wang Kun K Li Gang G Chen Lin L Hu Ping P
Nature communications 20180501 1
Age-related muscle atrophy (sarcopenia) is the leading cause for disability in aged population, but the underlying molecular mechanisms are poorly understood. Here we identify a novel role for the secreted glycoprotein Dickkopf 3 (Dkk3) in sarcopenia. Forced expression of Dkk3 in muscles in young mice leads to muscle atrophy. Conversely, reducing its expression in old muscles restores both muscle size and function. Dkk3 induces nuclear import of β-catenin and enhances its interaction with FoxO3, ...[more]