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In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source.

ABSTRACT: We describe the first dynamic and the first in vivo X-ray imaging studies successfully performed at a laser-undulator-based compact synchrotron light source. The X-ray properties of this source enable time-sequence propagation-based X-ray phase-contrast imaging. We focus here on non-invasive imaging for respiratory treatment development and physiological understanding. In small animals, we capture the regional delivery of respiratory treatment, and two measures of respiratory health that can reveal the effectiveness of a treatment; lung motion and mucociliary clearance. The results demonstrate the ability of this set-up to perform laboratory-based dynamic imaging, specifically in small animal models, and with the possibility of longitudinal studies.

SUBMITTER: Gradl R

PROVIDER: S-EPMC5931574 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source.

Gradl Regine R Dierolf Martin M Günther Benedikt B Hehn Lorenz L Möller Winfried W Kutschke David D Yang Lin L Donnelley Martin M Murrie Rhiannon R Erl Alexander A Stoeger Tobias T Gleich Bernhard B Achterhold Klaus K Schmid Otmar O Pfeiffer Franz F Morgan Kaye Susannah KS

Scientific reports 20180501 1

We describe the first dynamic and the first in vivo X-ray imaging studies successfully performed at a laser-undulator-based compact synchrotron light source. The X-ray properties of this source enable time-sequence propagation-based X-ray phase-contrast imaging. We focus here on non-invasive imaging for respiratory treatment development and physiological understanding. In small animals, we capture the regional delivery of respiratory treatment, and two measures of respiratory health that can rev ...[more]

PMID: 29717143

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