Ontology highlight
ABSTRACT:
SUBMITTER: da Silva AVA
PROVIDER: S-EPMC5931683 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
da Silva Aurea Virginia Andrade AVA Figueiredo Fabiano Borges FB Menezes Rodrigo Caldas RC Mendes-Junior Arthur Augusto AA de Miranda Luisa Helena Monteiro LHM Cupolillo Elisa E Porrozzi Renato R Morgado Fernanda Nazaré FN
PLoS neglected tropical diseases 20180420 4
The spleen is one of the main affected organs in canine visceral leishmaniasis (CVL). Disorganization of the splenic white pulp (SWP) has been associated with immunosuppression and disease progression. This study aims to assess structural and cellular changes in the splenic extracellular matrix of dogs with CVL, correlating these changes with the parasite load and clinical signs. Splenic fragments were collected from 41 naturally infected animals for parasite load quantification by quantitative ...[more]