Ontology highlight
ABSTRACT:
SUBMITTER: Bopp S
PROVIDER: S-EPMC5931971 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Bopp Selina S Magistrado Pamela P Wong Wesley W Schaffner Stephen F SF Mukherjee Angana A Lim Pharath P Dhorda Mehul M Amaratunga Chanaki C Woodrow Charles J CJ Ashley Elizabeth A EA White Nicholas J NJ Dondorp Arjen M AM Fairhurst Rick M RM Ariey Frederic F Menard Didier D Wirth Dyann F DF Volkman Sarah K SK
Nature communications 20180502 1
Multidrug resistant Plasmodium falciparum in Southeast Asia endangers regional malaria elimination and threatens to spread to other malaria endemic areas. Understanding mechanisms of piperaquine (PPQ) resistance is crucial for tracking its emergence and spread, and to develop effective strategies for overcoming it. Here we analyze a mechanism of PPQ resistance in Cambodian parasites. Isolates exhibit a bimodal dose-response curve when exposed to PPQ, with the area under the curve quantifying the ...[more]