Time-of-Day Effects on Metabolic and Clock-Related Adjustments to Cold.

ABSTRACT:

Background

Daily cyclic changes in environmental conditions are key signals for anticipatory and adaptive adjustments of most living species, including mammals. Lower ambient temperature stimulates the thermogenic activity of brown adipose tissue (BAT) and skeletal muscle. Given that the molecular components of the endogenous biological clock interact with thermal and metabolic mechanisms directly involved in the defense of body temperature, the present study evaluated the differential homeostatic responses to a cold stimulus at distinct time-windows of the light/dark-cycle.

Methods

Male Wistar rats were subjected to a single episode of 3 h cold ambient temperature (4°C) at one of 6 time-points starting at Zeitgeber Times 3, 7, 11, 15, 19, and 23. Metabolic rate, core body t

SUBMITTER: Machado FSM 

PROVIDER: S-EPMC5932155 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature